CALR_CAVPO/145-398..AYVLYYLAIVGHSMSIITLVVSLGI-FVYFRS-----------------------------LGCQRVT-LHKNMFLTYILNSMIIIIHLVEVVP-----------------------------------NGELVRKDPVS-------------------------------------CK-ILHFFHQYMMACNYFWMLCEGIYLHTLI------VVSVFNEAKHLRWYYLLGWGFPLVPTTIHAITR---------------ALYFNDNC-WISVD---THLLYIIHGPVMVALVVNFFFLLNIVRVLVTKMR--E-----THEAES---------------------YMYL-------------------------------------------------------KAVKATMILVPLLGIQFVVFPWRPSNK------VLGKIYDYFMHSLIHFQGFFVATIYCFCNNEV

CALR_HUMAN/145-414..AYVLYYLAIVGHSLSIFTLVISLGI-FVFFRK-------------LTTIFPLNWKYRKALSLGCQRVT-LHKNMFLTYILNSMIIIIHLVEVVP-----------------------------------NGELVRRDPVS-------------------------------------CK-ILHFFHQYMMACNYFWMLCEGIYLHTLI------VVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITR---------------AVYFNDNC-WLSVE---THLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMR--E-----THEAES---------------------HMYL-------------------------------------------------------KAVKATMILVPLLGIQFVVFPWRPSNK------MLGKIYDYVMHSLIHFQGFFVATIYCFCNNEV

CALR_MOUSE/145-435..AYVLYYLALVGHSLSIAALVASMLI-FWIFKN-----------------------------LSCQRVT-LHKHMFLTYILNSIIIIIHLVEVVP-----------------------------------NGDLVRRDPMHIFHHNTHMWTMQWELSPPLPLCAHEGKMDPHASEVISCK-VLHFLHQYMMSCNYFWMLCEGIYLHTLI------VMAVFTDEQRLRWYYLLGWGFPIVPTIIHAITR---------------ALYYNDNC-WLSAE---THLLYIIHGPVMVALVVNFFFLLNIVRVLVTKMR--Q-----THEAES---------------------YMYL-------------------------------------------------------KAVKATMVLVPLLGIQFVVFPWRPSNK------VLGKIYDYLMHSLIHFQGFFVATIYCFCNHEV

CALR_PIG/146-415....AYILYYLAIVGHSLSILTLLISLGI-FMFLRY-------------FNLLAPFNALLYPTRSISCQRVT-LHKNMFLTYVLNSIIIIVHLVVIVP-----------------------------------NGELVKRDPPI-------------------------------------CK-VLHFFHQYMMSCNYFWMLCEGVYLHTLI------VVSVFAEGQRLWWYHVLGWGFPLIPTTAHAITR---------------AVLFNDNC-WLSVD---TNLLYIIHGPVMAALVVNFFFLLNILRVLVKKLK--E-----SQEAES---------------------HMYL-------------------------------------------------------KAVRATLILVPLLGVQFVVLPWRPSTP------LLGKIYDYVVHSLIHFQGFFVAIIYCFCNHEV

CALR_RABIT/145-398..AYVLYYLAIVGHSLSIFTLVISLGI-FKCFRS-----------------------------LGCQRVT-LHKNMFLTYILNSMIIIIHLVEVVP-----------------------------------NGELVRRDPVS-------------------------------------CK-VLHFFHQYMMSCNYFWMLCEGIYLHTLI------VVAVFAKQQHLRWYYLLGWGFPLVPTTIHAITR---------------AIYFNDNC-WMSVE---THLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMR--E-----TLEAES---------------------HMYL-------------------------------------------------------KAVKATMILVPLLGIQFVVFPWRPSNK------ILGKIYDYLMHSLIHFQGFFVATIYCFCNNEV

CALR_RAT/145-435....AYVLYYLALVGHSMSIAALIASMGI-FLFFKN-----------------------------LSCQRVT-LHKNMFLTYILNSIIIIIHLVEVVP-----------------------------------NGDLVRRDPMHIFHHNTYMWTMQWELSPPLPLSAHEGKMDPHDSEVISCK-ILHFFHQYMMACNYFWMLCEGIYLHTLI------VMAVFTEDQRLRWYYLLGWGFPIVPTIIHAITR---------------AVYYNDNC-WLSTE---THLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMR--Q-----THEAEA---------------------YMYL-------------------------------------------------------KAVKATMVLVPLLGIQFVVFPWRPSNK------VLGKIYDYLMHSLIHFQGFFVATIYCFCNHEV

CAR1_DICDI/11-264...ETSLVLLLFADFSSMLGCMAVLIGF----WR------------------------------LKLLRNH-VTKVIACFCATSFCKDFPSTILTLTNTAVNGG--------------------------------------------------------------------------FPCY-LYAIVITYGSFACWLWTLCLAISIYMLI------VKREPEPERFEKYYYLLCWGLPLISTIVMLAKN--------------TVQFVGNWC-WIGVSFTGYRFGLFY-GPFLFIWAISAVLVGLTSRYTYVVIHN-G----VSDNKEKHL--------------------TYQ------------------------------------------------------FKLINYIIVFLVCWVFAVVNRIVNGLN-------MFPPALNILHTYLSVSHGFWASVTFIYNNPLM

CD97_HUMAN/451-700..DWKLTLITRVGLALSLFCLLLCILT-FLLVRP-----------------------------IQGSRTT-IHLHLCICLFVGSTIFLAGIENEGGQVG------------------------------------------------------------------------------LRCR-LVAGLLHYCFLAAFCWMSLEGLELYFLV------VRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIY-------------SKGYGRPRYC-WLDFE---QGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFS--E-----INPDMKKL-------------------KKA-----------------------------------------------------RAL-TITA-IAQLFLLGCTWVFGLFIFDD--------RSLVLTYVFTILNCLQGAFLYLLHCLLNKKV

CG12370.............VELPAIIYAGGYFLSFATLVVALII-FLSFKD-----------------------------LRCLRNT-IHANLFLTYITSALLWILTLFLQVITSQAG------------------------------------------------------------------------------CI-TLVIMFQYFYLTNFFWMFVEGLYLYTLV------VQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEID-----CAWMRES----HIDWIFKVPASLALLVNLVFLIRIMWVLITKLR----------------------------------------------------------------------------------------------KASKALLVLIPLFGITYLLVLTGP-EQG-----ISRNLFEAIRAFLISTQGFFVALFYCFLNSEV

CG13758.............ARRTRTLEIVGLCLSLFALIVSLLI-FCTFRS-----------------------------LRNNRTK-IHKNLFVAMVLQVIIRLTLYLDQFRRN-TMP---------------------------------------------------------------------------YLCE-ASYVLLEYARTAMFMWMFIEGLYLHNMV------TVAVFQGSFPLKFFSRLGWCVPILMTTVWARCT------------VMYMDTSLGECLWNYN---LTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLR----------------------------------------------------------------------------------------------KAVRAAIVLLPLLGITNLLHQLAPLKTA-----TNFAVWSYGTHFLTSFQGFFIALIYCFLNGEV

CG17415.............RHTVNLISEVGYGTSLLAILLSLAI-LGYFNN-----------------SIRIFVFRLNRSLKCARIT-LHMNLFASFAANNSLWLVWYLLVMP-----------------------------------NSELLHQSPMR-------------------------------------CV-ALHITLHYFLLSNYSWMLCEGFYLHTVL------VAAFISEKRLVKWLIAFGWGSPAIVIFVYSMAR-----------GLGGTPEDNRHC-WMNQT----NYQNILMVPVCISMFLNLLFLCNIVRVVLLKLNA-P-ASIQGSCGPSRT--------------------VLQ--------------------------------------------------------AFRATLLLVPLLGLQYILTPFRPAPKH-----PWENTYEIISAFTASFQGLCVAILFCFCNGEV

CG4395..............RQFINELYVKGYALSLLALLISIII-FLGFKS-----------------------------LRCTRIR-IHVHLFASLACTCVAWILWYRLVVEI----------------------------------NIT----------------------------------------NFQLWCI-GLHLVVHYFMLVNYFWMFCEGLHLHLVL------VVVALRLRQVEMSGMSVQILTPLLLSIRQVFVK---------------DTIVMRCC-WITDS---LYLWIFSYAIAQLYAFYPTVFLINVLRVIVRKL---H-----PQSAQPAP-------------------LAIR-------------------------------------------------------KAVRATIILVPLFGLQHFLLPYRPDAGT-----QLDHFYQMLSVVLVSLQGFVVSFLFCFANHDV

CG8422..............VELPTIIYYIGYTLSLVSLSLALIV-FAYFKE-----------------------------LRCLRNT-IHANLFFTYIMSALFWILLLSVQISIVGS-------------------------------------------------------------------------------CI-ALITLFHFFTLTNFFWMLVEGLYLYMLV------VKTFSGDNLRFNIYASIGWGGPALFVVTWAVAKSLTVTYSTP--EKYEIN-----CPWMQET----HVDWIYQGPVCAVLIINLTFLLRIMWVLITKLR----------------------------------------------------------------------------------------------KAAKALLVLIPLFGITYLVVLAGPSESG-----LMGHMFAVLRAVLLSTQGFSVSLFYCFLNSEV

CGRR_HUMAN/138-391..ALNLFYLTIIGHGLSIASLLISLGI-FFYFKS-----------------------------LSCQRIT-LHKNLFFSFVCNSVVTIIHLTAVAN-----------------------------------NQALVATNPVS-------------------------------------CK-VSQFIHLYLMGCNYFWMLCEGIYLHTLI------VVAVFAEKQHLMWYYFLGWGFPLIPACIHAIAR---------------SLYYNDNC-WISSD---THLLYIIHGPICAALLVNLFFLLNIVRVLITKLK--V-----THQAES---------------------NLYM-------------------------------------------------------KAVRATLILVPLLGIEFVLIPWRPEGK------IAEEVYDYIMHILMHFQGLLVSTIFCFFNGEV

CGRR_RAT/138-391....ALNLFYLTIIGHGLSIASLIISLII-FFYFKS-----------------------------LSCQRIT-LHKNLFFSFVCNSIVTIIHLTAVAN-----------------------------------NQALVATNPVS-------------------------------------CK-VSQFIHLYLMGCNYFWMLCEGIYLHTLI------VVAVFAEKQHLMWYYFLGWGFPLLPACIHAIAR---------------SLYYNDNC-WISSD---THLLYIIHGPICAALLVNLFFLLNIVRVLITKLK--V-----THQAES---------------------NLYM-------------------------------------------------------KAVRATLILVPLLGIEFVLFPWRPEGK------VAEEVYDYVMHILMHYQGLLVSTIFCFFNGEV

CRF2_HUMAN/113-366..YRIALVVNYLGHCVSVAALVAAFLL-FLALRS-----------------------------IRCLRNV-IHWNLITTFILRNVMWFLLQLVD-HEV--------------------------------------------------------------------------HESNEVWCH-CITTIFNYFVVTNFFWMFVEGCYLHTAI------VMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGK---------------LYYENEQC-WFGKE-PGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRA-S-----TTSETI----------------------QYR-------------------------------------------------------KAVKATLVLLPLLGITYMLFFVNPGEDD-----LSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEV

CRF2_MOUSE/133-386..YRIALIVNYLGHCVSVVALVAAFLL-FLVLRS-----------------------------IRCLRNV-IHWNLITTFILRNIAWFLLQLID-HEV--------------------------------------------------------------------------HEGNEVWCR-CITTIFNYFVVTNFFWMFVEGCYLHTAI------VMTYSTEHLRKWLFLFIGWCIPCPIIIAWAVGK---------------LYYENEQC-WFGKE-AGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRA-S-----TTSETI----------------------QYR-------------------------------------------------------KAVKATLVLLPLLGITYMLFFVNPGEDD-----LSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEV

CRF2_RAT/113-366....YRIALIINYLGHCVSVVALVAAFLL-FLVLRS-----------------------------IRCLRNV-IHWNLITTFILRNITWFLLQLID-HEV--------------------------------------------------------------------------HEGNEVWCR-CVTTIFNYFVVTNFFWMFVEGCYLHTAI------VMTYSTEHLRKWLFLFIGWCIPCPIIVAWAVGK---------------LYYENEQC-WFGKE-PGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRA-S-----TTSETI----------------------QYR-------------------------------------------------------KAVKATLVLLPLLGITYMLFFVNPGEDD-----LSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEV

CRF2_XENLA/115-368..YKIALIINYLGHCISILALVIAFLL-FLCLRS-----------------------------IRCLRNI-IHWNLITTFILRNIMWFLLQMID-HNI--------------------------------------------------------------------------HESNEVWCR-CITTIYNYFVVTNFFWMFVEGCYLHTAI------VMTYSTDKLRKWVFLFIGWCIPSPIIVTWAICK---------------LFYENEQC-WIGKE-PGKYIDYIYQGRVILVLLINFVFLFNIVRILMTKLRA-S-----TTSETI----------------------QYR-------------------------------------------------------KAVKATLVLLPLLGITYMLFFVNPGEDD-----VSQIVFIYFNSFLQSFQGFFVSVFYCFLNGEV

CRFR_CHICK/121-375..YHIAVIINYLGHCVSLGTLLVAFVL-FMRLRS-----------------------------IRCLRNI-IHWNLITAFILRNATWFVVQLTMNPEV--------------------------------------------------------------------------HESNVVWCR-LVTAAYNYFHVTNFFWMFGEGCYLHTAI------VLTYSTDKLRKWMFICIGWCIPFPIIVAWAIGK---------------LYYDNEKC-WFGKR-AGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA-S-----TTSETI----------------------QYR-------------------------------------------------------KAVKATLVLLSLLGITYMLFFVNPGEDE-----ISRIVFIYFNSFLESFQGFFVSVFYCFLNSEV

CRFR_HUMAN/116-399..YHVAVIINYLGHCISLVALLVAFVL-FLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNI-IHWNLISAFILRNATWFVVQLTMSPEV--------------------------------------------------------------------------HQSNVGWCR-LVTAAYNYFHVTNFFWMFGEGCYLHTAI------VLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGK---------------LYYDNEKC-WFGKR-PGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA-S-----TTSETI----------------------QYR-------------------------------------------------------KAVKATLVLLPLLGITYMLFFVNPGEDE-----VSRVVFIYFNSFLESFQGFFVSVFYCFLNSEV

CRFR_MOUSE/116-370..YHIAVIINYLGHCISLVALLVAFVL-FLRLRS-----------------------------IRCLRNI-IHWNLISAFILRNATWFVVQLTVSPEV--------------------------------------------------------------------------HQSNVAWCR-LVTAAYNYFHVTNFFWMFGEGCYLHTAI------VLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGK---------------LYYDNEKC-WFGKR-PGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA-S-----TTSETI----------------------QYR-------------------------------------------------------KAVKATLVLLPLLGITYMLFFVNPGEDE-----VSRVVFIYFNSFLESFQGFFVSVFYCFLNSEV

CRFR_RAT/116-370....YHVAVIINYLGHCISLVALLVAFVL-FLRLRS-----------------------------IRCLRNI-IHWNLISAFILRNATWFVVQLTVSPEV--------------------------------------------------------------------------HQSNVAWCR-LVTAAYNYFHVTNFFWMFGEGCYLHTAI------VLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGK---------------LHYDNEKC-WFGKR-PGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA-S-----TTSETI----------------------QYR-------------------------------------------------------KAVKATLVLLPLLGITYMLFFVNPGEDE-----VSRVVFIYFNSFLESFQGFFVSVFYCFLNSEV

CRFR_SHEEP/116-370..YHIAVIINYLGHCISLAALLVAFVL-FLRLRS-----------------------------IRCVRNI-IHWNLISAFILRNATWFVVQLTMSPEV--------------------------------------------------------------------------HQSNVGWCR-LVTAAYNYFHVTNFFWMFGEGCYLHTAV------VLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGK---------------LYYDNEKC-WFGKR-PGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA-S-----TTSETI----------------------QYR-------------------------------------------------------KAVKATLVLLPLLGITYMLFFVNPGEDE-----VSRVVFIYFNSFLESFQGFFVSVFYCFLNSEV

CRFR_XENLA/116-370..YHIAIVINFLGHSISLCALLVAFIL-FLRLRS-----------------------------IRCLRNI-IHWNLITAFILRNVTWFVMQLTLSHEA--------------------------------------------------------------------------HDSNVVWCR-LVTIAHNYFYVTNFFWMFGEGCYLHTAI------VLTYSTDKLRKWMFICIGWCIPFPIIVAWAIGK---------------LYYDNEKC-WFGKK-AGVYTDFIYQGPVILVLLINFIFLFNIVRILMTKLRA-S-----TTSETI----------------------QYR-------------------------------------------------------KAVKATLVLLPLLGITYMLFFVTPGEDE-----ISRIVFIYFNSFLQSFQGFFVSVFYCFLNSEV

DIHR_ACHDO/130-393..DAAMAFVFFVGFCLSLVAIAVAIWI-FLYFKD-----------------------------LRCLRNT-IHTNLMATYICNDATWIISAVVQEYVENGGL-----------------------------------------------------------------------------CS-VLAVLMHYFYLTNFFWMFVEGLYLFLLV------VATFTGEKVKLQIYIIIGWGIPGVIVVTWAIIKHLGKTAPDNAGESHPMVLLIKHCPWMAED----YFDWIHQAPVITVLAVNLVFLFSIMWVLITKLQS-A-----NTAETQ----------------------QYR-------------------------------------------------------KATKALLVLFPLLGITYILMMQGPMDG------VAGHVFRNAQALLLSLQGFTVALFYCFLNTEV

DIHR_MANSE/83-351...TDVASLIYLAGYSLSLAVLSLAVFV-FLYFKD-----------------------------LRCLRNT-IHTNLMSTYILSACSWILNLVLQNWSDESQQDQTS-------------------------------------------------------------------------CM-ILVICMNYFYLTNFFWMLVEGLYLYMLV------VETFTAENIKLKVYTTIGWGAPAVFITIWVISRCFVNVLPSTGPDGLAMFPEAKMCIWMHEH----QVDWIHKAPALVGLALNLFFLIRIMWVLITKLRS-A-----NTLETE----------------------QYR-------------------------------------------------------KATKALLVLIPLLGITNLLVLCGPSDDS-----WFAYAFDYTRALMLSTQGFTVALFYCFMNTEV

EMR1_HUMAN/599-851..DFSLYIISHVGIIISLVCLVLAIAT-FLLCRS-----------------------------IRNHNTY-LHLHLCVCLLLAKTLFLAGIHKTDNKTG--------------------------------------------------------------------------------CA-IIAGFLHYLFLACFFWMLVEAVILFLMVRNL-KVVNYFSSRNIKMLHICAFGYGLPMLVVVISASVQ-------------PQGYGMHNRC-WLNTE---TGFIWSFLGPVCTVIVINSLLLTWTLWILRQRLS--S-----VNAEVSTL-------------------KDT-----------------------------------------------------RLL-TFKA-FAQLFILGCSWVLGIFQIGP--------VAGVMAYLFTIINSLQGAFIFLIHCLLNGQV

EMR1_MOUSE/644-896..EFSLYIISHVGTVISLVCLALAIAT-FLLCRA-----------------------------VQNHNTY-MHLHLCVCLFLAKILFLTGIDKTDNQTA--------------------------------------------------------------------------------CA-IIAGFLHYLFLACFFWMLVEAVMLFLMVRNL-KVVNYFSSRNIKMLHLCAFGYGLPVLVVIISASVQ-------------PRGYGMHNRC-WLNTE---TGFIWSFLGPVCMIITINSVLLAWTLWVLRQKLC--S-----VSSEVSKL-------------------KDT-----------------------------------------------------RLL-TFKA-IAQIFILGCSWVLGIFQIGP--------LASIMAYLFTIINSLQGAFIFLIHCLLNRQV

GIPR_HUMAN/134-399..LERLQVMYTVGYSLSLATLLLALLI-LSLFRR-----------------------------LHCTRNY-IHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQAL----------------------------------------------------------------AACR-TAQIVTQYCVGANYTWLLVEGVYLHSLL------VLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVR---------------YLYENTQC-WERNE--VKAIWWIIRTPILMTILINFLIFIRILGILLSKLRT-R---QMRCRDYR-----------------------LR--------------------------------------------------------LARSTLTLVPLLGVHEVVFAPVTEEQARG---ALRFAKLGFEIFLSSFQGFLVSVLYCFINKEV

GIPR_MESAU/131-396..LERLQVVYTVGYSLSLGTLLLALLI-LSLFRR-----------------------------LHCTRNY-IHMNVFLSFMLRAVAILTRDRLLPTLGPYPGDRTLTLRNQAL----------------------------------------------------------------AACR-TAQIVTQYCVGANYTWLLVEGVYLHHLL------VIVGGSEKGHFRCYLLLGWGAPALFVIPWVIVR---------------YLLENTQC-WERNE--VKAIWWIIRTPILITILINFFIFIRILGILVSKLRT-R---QMRCPDYR-----------------------LR--------------------------------------------------------LARSTLTLVPLLGVHEVVFAPVTEEQAEG---TLRFAKLAFEIFLSSFQGFLVSVLYCFINKEV

GIPR_RAT/131-396....LERLQVVYTVGYSLSLATLLLALLI-LSLFRR-----------------------------LHCTRNY-IHMNLFTSFMLRAGAILTRDQLLPPLGPYTGNQTPTLWNQAL----------------------------------------------------------------AACR-TAQILTQYCVGANYTWLLVEGVYLHHLL------VVVRRSEKGHFRCYLLLGWGAPALFVIPWVIVR---------------YLYENTQC-WERNE--VKAIWWIIRTPILITILINFLIFIRILGILVSKLRT-R---QMRCPDYR-----------------------LR--------------------------------------------------------LARSTLTLMPLLGVHEVVFAPVTEEQAEG---SLRFAKLAFEIFLSSFQGFLVSVLYCFINKEV

GLPR_HUMAN/141-409..LLFLYIIYTVGYALSFSALVIASAI-LLGFRH-----------------------------LHCTRNY-IHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDS-------------------------------------------------------------LSCR-LVFLLMQYCVAANYYWLLVEGVYLYTLL------AFSVFSEQWIFRLYVSIGWGVPLLFVVPWGIVK---------------YLYEDEGC-WTRNS--NMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKA-N---LMCKTDIK-----------------------CR--------------------------------------------------------LAKSTLTLIPLLGTHEVIFAFVMDEHARG---TLRFIKLFTELSFTSFQGLMVAILYCFVNNEV

GLPR_MOUSE/141-409..LLSLYIIYTVGYALSFSALVIASAI-LVGFRH-----------------------------LHCTRNY-IHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDS-------------------------------------------------------------LGCR-LVFLLMQYCVAANYYWLLVEGVYLYTLL------AFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVK---------------YLYEDEGC-WTRNS--NMNYWLIIRLPILFAIGVNFLIFIRVICIVVSKLKA-N---LMCKTDIK-----------------------CR--------------------------------------------------------LAKSTLTLIPLLGTHEVIFAFVMDEHARG---TLRFIKLFTELSFTSFQGLMVAILYCFVNNEV

GLPR_RAT/141-409....LLSLYIIYTVGYALSFSALVIASAI-LVSFRH-----------------------------LHCTRNY-IHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDS-------------------------------------------------------------LGCR-LVFLLMQYCVAANYYWLLVEGVYLYTLL------AFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVK---------------YLYEDEGC-WTRNS--NMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKA-N---LMCKTDIK-----------------------CR--------------------------------------------------------LAKSTLTLIPLLGTHEVIFAFVMDEHARG---TLRFVKLFTELSFTSFQGFMVAVLYCFVNNEV

GLR_HUMAN/138-407...YSSFQVMYTVGYSLSLGALLLALAI-LGGLSK-----------------------------LHCTRNA-IHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAV------------------------------------------------------------AGCR-VAAVFMQYGIVANYCWLLVEGLYLHNLL------GLATLPERSFFSLYLGIGWGAPMLFVVPWAVVK---------------CLFENVQC-WTSND--NMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRA-R---QMHHTDYK-----------------------FR--------------------------------------------------------LAKSTLTLIPLLGVHEVVFAFVTDEHAQG---TLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEV

GLR_MOUSE/139-408...YSSQQVMYTVGYSLSLGALLLALVI-LLGLRK-----------------------------LHCTRNY-IHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAM------------------------------------------------------------AGCR-VATVIMQYGIIPNYCWLLVEGVYLYSLL------SLATFSERSFFSLYLGIGWGAPLLFVIPWVVVK---------------CLFENVQC-WTSND--NMGFWWILRIPVFLALLINFFIFVHIIQLLVAKLRA-H---QMHYADYK-----------------------FR--------------------------------------------------------LARSTLTLIPLLGVHEVVFAFVTDEHAQG---TLRSTKLFFDLFLSSFQGLLVAVLYCFLNKEV

GLR_RAT/139-408.....YSSYQVMYTVGYSLSLGALLLALVI-LLGLRK-----------------------------LHCTRNY-IHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAV------------------------------------------------------------AGCR-VATVIMQYGIIANYCWLLVEGVYLYSLL------SITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVK---------------CLFENVQC-WTSND--NMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRA-H---QMHYADYK-----------------------FR--------------------------------------------------------LARSTLTLIPLLGVHEVVFAFVTDEHAQG---TLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEV

GRFR_HUMAN/126-383..FSTVKIIYTVGHSISIVALFVAITI-LVALRR-----------------------------LHCPRNY-VHTQLFTTFILKAGAVFLKDAALFHSD-DTDHCSFST---------------------------------------------------------------------VLCK-VSVAASHFATMTNFSWLLAEAVYLNCLL------ASTSPSSRRAFWWLVLAGWGLPVLFTGTWVSCK---------------LAFEDIAC-WDLDD--TSPYWWIIKGPIVLSVGVNFGLFLNIIRILVRKLEP-----AQGSLHTQSQ---------------------Y-------------------------------------------------------WRLSKSTLFLIPLFGIHYIIFNFLPDN-------AGLGIRLPLELGLGSFQGFIVAILYCFLNQEV

GRFR_MOUSE/126-383..FSTVKIIYTTGHSISIVALCVAIAI-LVALRR-----------------------------LHCPRNY-IHTQLFATFILKASAVFLKDAAIFQGD-STDHCSMST---------------------------------------------------------------------VLCK-VSVAISHLATMTNFSWLLAEAVYLSCLL------ASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCK---------------HSFEDTEC-WDLDN--SSPCWWIIKGPIVLSVGVNFGLFLNIICILLRKLEP-----AQGGLHTRAQ---------------------Y-------------------------------------------------------WRLSKSTLLLIPLFGIHYIIFNFLPDS-------AGLDIRVPLELGLGSFQGFIVAVLYCFLNQEV

GRFR_PIG/126-383....FSTVRIVYTTGHSVSAVALFVAIAI-LVALRR-----------------------------LHCPRNY-IHSQLFATFILKAGAVFLKDAALFHSE-NTDHCSFST---------------------------------------------------------------------VLCK-VSVATSHFATMTNFSWLLAEAVYLTCLL------ASTSPSTRRAFWWLVLAGWGLPLLFTGTWVGCK---------------LAFEDVAC-WDLDD--SSPYWWIIKGPIVLSVGVNFGLFLNIIRILLRKLEP-----AQGSLHTQPQ---------------------Y-------------------------------------------------------WRLSKSTLLLIPLFGIHYVIFNFLPDS-------AGLGIRLPLELGLGSFQGFIVAILYCFLNQEV

GRFR_RAT/126-424....FSTVKIIYTTGHSISIVALCVAIAI-LVALRR-----------------------------LHCPRNY-IHTQLFATFILKASAVFLKDAAVFQGD-STDHCSMST---------------------------------------------------------------------ILCK-VSVAVSHFATMTNFSWLLAEAVYLSCLL------ASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCK---------------LAFEDTAC-WDLDD--SSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGP-----AQGGLHTRAQ---------------------YCNYLLPWSCPLPQVPRERTDLGPS--------------SHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDS-------AGLGIRLPLELGLGSFQGFVVAVLYCFLNQEV

O00406/622-883......MMALTFITYIGCGLSSIFLSVTLVTYIAFEKI-----------------------------RRDYPSK-ILIQLCAALLLLNLVFLLDSWIALYKMQGL------------------------------------------------------------------------------CI-SVAVFLHYFLLVSFTWMGLEAFHMYLAL-----VKVFNTYIRKYILKFCIVGWGVPAVVVTIILTISPDNYG--LGSYGKFPNGSPDDFC-WINNN---AVFYITVVGYFCVIFLLNVSGMFIVVLVQLCRIKK-K--KQLGAQRKTS----------------------IQ--------------------------------------------------------DLRSIAGLTFLLGITWGFAFFAWGP--------VNVTFMYLFAIFNTLQGFFIFIFYCVAKENV

O14514/944-1191.....ATLPSVTLIVGCGVSSLTLLMLVIIYVSVWRY-----------------------------IRSERSV-ILINFCLSIISSNALILIGQTQTRNKVM--------------------------------------------------------------------------------CT-LVAAFLHFFFLSSFCWVLTEAWQSYMAV------TGHLRNRLIR-KRFLCLGWGLPALVVAISVGFTK------------AKGYSTMNYC-WLSLE---GGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITD-----KKLKERAG------------------------------------------------------------------------------ASLWSSCVVLPLLALTWMSAVLAVTDR-------RSALFQILFAVFDSLEGFVIVMVHCILRREV

O35161/2480-2723....VLPLKIITYAALSLSLVALLVAFVL-LSLVRT-----------------------------LRSNLHS-IHKNLIAALFFSQLIFMVGINQTENPFL--------------------------------------------------------------------------------CT-VVAILLHYVSMGTFAWTLVENLHVYRML------TEVRNIDTGPMRFYHVVGWGIPAIVTGLAVGLD-------------PQGYGNPDFC-WLSLQ---DTLIWSFAGPVGTVIIINTVIFVLSAKV--------S-----CQRKHHYY-------------------ERK-----------------------------------------------------GVVSMLRTAFLLLLLVTATWLLGLLAVNS--------DTLSFHYLFAAFSCLQGIFVLLFHCVAHREV

O57671/1-126........------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NFFWLLVEGLYLHSLI------FMAFFSEKKYLWGFTLFGWGLPAVFVTAWASVR---------------ATLADTEC-WDLS---AGNFKWIIQVPILAAIVVNFILLGLIVYILVKKLR--CDP-HLERIQYRQQ---------------------YR-------------------------------------------------------KLLKSTLVLIPLFGIH-------------------------------------------------

O60241/917-1197.....AGSPSVPLVIGCAVSCMALLTLLAIYAAFWRF-----------------------------IKSERSI-ILLNFCLSILASNILILVGQSRVLSKGV--------------------------------------------------------------------------------CT-MTAAFLHFFFLSSFCWVLTEAWQSYLAV------IGRMRTRLVR-KRFLCLGWGLPALVVAVSVGFTR------------TKGYGTSSYC-WLSLE---GGLLYAFVGPAAVIVLVNMLIGIIVFNKLMARDGISD-----KSKKQRAG-------------------SERCPWASLLLPCSACGAVPSPLLSSASAR--------------------------NAMASLWSSCVVLPLLALTWMSAVLAMTDR-------RSVLFQALFAVFNSAQGFVITAVHCFLRREV

O60242/874-1154.....SGTPSVTLIVGSGLSCLALITLAVVYAALWRY-----------------------------IRSERSI-ILINFCLSIISSNILILVGQTQTHNKSI--------------------------------------------------------------------------------CT-TTTAFLHFFFLASFCWVLTEAWQSYMAV------TGKIRTRLIR-KRFLCLGWGLPALVVATSVGFTR------------TKGYGTDHYC-WLSLE---GGLLYAFVGPAAAVVLVNMVIGILVFNKLVSRDGILD-----KKLKHRAG-------------------QMSEPHSGLTLKCAKCGVVSTTALSATTAS--------------------------NAMASLWSSCVVLPLLALTWMSAVLAMTDK-------RSILFQILFAVFDSLQGFVIVMVHCILRREV

O73768/133-390......LSTLKQLYTAGYATSLISLITAVII-FTCFRK-----------------------------FHCTRNY-IHINLFVSFILRATAVFIKDAVLFSDE-TQNHCLMST---------------------------------------------------------------------VACK-TAVTFFQFCILTNYFWLLVEGLYLQTIL------TLTFVSQRKYFWWYILIGWGVPSVVLIVWVLTR---------------QFYDNRGC-WDDTD--NMNIWWIIKGPITVSLIANIIIFLNVIRILVQKLKS-P---GVGGNDTGH---------------------FMR--------------------------------------------------------LAKSTLFLIPLFGMHYTLFAFLPEN-------TGEIVRFYIELGLGSFQGFVVALLYCFLNGDV

O73769/142-399......YASVKALYTVGYSTSLVSLTTAMVI-LCRFRK-----------------------------LHCTRNF-IHMNLFVSFMLRAISVFIKDGVLYAEE-DSDHCFVHT---------------------------------------------------------------------VGCK-AVMVFFHYCVMSNYFWLFIEGLYLFTLL------VETFFPERRYFYWYTIIGWGTPTICVTIWAVLR---------------LHFDDSGC-WDMND--NTALWWVIKGPVVASIMINFVLFIGIIIILVQKLQS-P---DIGGNESSI---------------------YLR--------------------------------------------------------LARSTLLLIPLFGIHYTVFAFSPED-------FSKRERLVFELGLGSFQGFVVAVLYCFLNGEV

O75092/588-830......LELLAVFTHVVVAVSVAALVLTAAI-LLSLRS-----------------------------LKSNVRG-IHANVAAALGVAELLFLLGIHRTHNQLV--------------------------------------------------------------------------------CT-AVAILLHYFFLSTFAWLFVQGLHLYRMQ------VEPRNVDRGAMRFYHALGWGVPAVLLGLAVGLD-------------PEGYGNPDFC-WISVH---EPLIWSFAGPVVLVIVMNGTMFLLAART--------S-----CSTGQREA-------------------KKT-----------------------------------------------------SAL-TLRSSFLLLLLVSASWLFGLLAVNH--------SILAFHYLHAGLCGLQGLAVLLLFCVLNADA

O88278/2534-2777....LELLAVFTHVVVAASVTALVLTAAV-LLSLRS-----------------------------LKSNVRG-IHANVAAALGVAELLFLLGIHRTHNQLL--------------------------------------------------------------------------------CT-VVAILLHYFFLSTFAWLLVQGLHLYRMQ------VEPRNVDRGAMRFYHALGWGVPAVLLGLAVGLD-------------PEGYGNPDFC-WISIH---EPLIWSFAGPIVLVIVMNGIMFLLAART--------S-----CSTGQREA-------------------KKT-----------------------------------------------------SVLRTLRSSFLLLLLVSASWLFGLLAVNH--------SVLAFHYLHAGLCGLQGLAVLLLFCVLNADA

O88916/851-1098.....ELLLSVITWVGIVISLVCLAICIST-FCFLRG-----------------------------LQTDRNT-IHKNLCINLFLAELLFLVGIDKTQYEVA--------------------------------------------------------------------------------CP-IFAGLLHYFFLAAFSWLCLEGVHLYLLL------VEVFESEYSRTKYYYLGGYCFPALVVGIAAAID-------------YRSYGTEKAC-WLRVD---NYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSS--V-----LKPDSSRL-------------------DNIK-------------------------------------------------------SWALGAIALLFLLGLTWAFGLLFINK--------ESVVMAYLFTTFNAFQGVFIFVFHCALQKKV

O88923/848-1110.....KLLLTVITWVGIVVSLVCLAICIFT-FCFFRG-----------------------------LQSDRNT-IHKNLCINLFIAEFIFLIGIDKTQYTIA--------------------------------------------------------------------------------CP-VFAGLLHFFFLAAFSWMCLEGVQLYLML------VEVFESEYSRKKYYYVAGYLFPATVVGVSAAID-------------YKSYGTLEAC-WLHVD---NYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSN--T-----LKPDSSRL-------------------ENINNYRVCDGYYNTDLPG----------------------------------------SWVLGAFALLCLLGLTWSFGLLFVNE--------ETVVMAYLFTAFNAFQGLFIFIFHCALQKKV

O88927/941-1188.....DLLLDVITWVGILLSLVCLLICIFT-FCFFRG-----------------------------LQSDRNT-IHKNLCISLFVAELLFLIGINRTDQPIA--------------------------------------------------------------------------------CA-VFAALLHFFFLAAFTWMFLEGVQLYIML------VEVFESEHSRRKYFYLVGYGMPALIVAVSAAVD-------------YRSYGTDKVC-WLRLD---TYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTA--I-----LKPESGCL-------------------DNIK-------------------------------------------------------SWVIGAIALLCLLGLTWAFGLMYINE--------STVIMAYLFTIFNSLQGMFIFIFHCVLQKKV

O94867/286-533......DLLLDVITWVGILLSLVCLLICIFT-FCFFRG-----------------------------LQSDRNT-IHKNLCISLFVAELLFLIGINRTDQPIA--------------------------------------------------------------------------------CA-VFAALLHFFFLAAFTWMFLEGVQLYIML------VEVFESEHSRRKYFYLVGYGMPALIVAVSAAVD-------------YRSYGTDKVC-WLRLD---TYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTA--I-----LKPESGCL-------------------DNIK-------------------------------------------------------SWVIGAIALLCLLGLTWAFGLMYINE--------STVIMAYLFTIFNSLQGMFIFIFHCVLQKKV

O94910/857-1104.....ELLLSVITWVGIVISLVCLAICIST-FCFLRG-----------------------------LQTDRNT-IHKNLCINLFLAELLFLVGIDKTQYEIA--------------------------------------------------------------------------------CP-IFAGLLHYFFLAAFSWLCLEGVHLYLLL------VEVFESEYSRTKYYYLGGYCFPALVVGIAAAID-------------YRSYGTEKAC-WLRVD---NYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSS--V-----LKPDSSRL-------------------DNIK-------------------------------------------------------SWALGAIALLFLLGLTWAFGLLFINK--------ESVVMAYLFTTFNAFQGVFIFVFHCALQKKV

O95490/831-1078.....ELLLTVITWVGIVISLVCLAICIFT-FCFFRG-----------------------------LQSDRNT-IHKNLCINLFIAEFIFLIGIDKTKYAIA--------------------------------------------------------------------------------CP-IFAGLLHFFFLAAFAWMCLEGVQLYLML------VEVFESEYSRKKYYYVAGYLFPATVVGVSAAID-------------YKSYGTEKAC-WLHVD---NYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSN--T-----LKPDSSRL-------------------ENIK-------------------------------------------------------SWVLGAFALLCLLGLTWSFGLLFINE--------ETIVMAYLFTIFNAFQGVFIFIFHCALQKKV

O95722/928-1171.....VLPLKIVTYAAVSLSLAALLVAFVL-LSLVRM-----------------------------LRSNLHS-IHKHLAVALFLSQLVFVIGINQTENPFL--------------------------------------------------------------------------------CT-VVAILLHYIYMSTFAWTLVESLHVYRML------TEVRNIDTGPMRFYYVVGWGIPAIVTGLAVGLD-------------PQGYGNPDFC-WLSLQ---DTLIWSFAGPIGAVIIINTVTSVLSAKV--------S-----CQRKHHYY-------------------GKK-----------------------------------------------------GIVSLLRTAFLLLLLISATWLLGLLAVNR--------DALSFHYLFAIFSGLQGPFVLLFHCVLNQEV

O95838/175-443......LSTLQLMYTVGYSFSLISLFLALTL-LLFLRK-----------------------------LHCTRNY-IHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYL-------------------------------------------------------------SEMSTSCR-SVQVLLHYFVGANYLWLLVEGLYLHTLL------EPTVLPERRLWPRYLLLGWAFPVLFVVPWGFAR---------------AHLENTGC-WTTNG--NKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKA-H---QMCFRDYK-----------------------YR--------------------------------------------------------LAKSTLVLIPLLGVHEILFSFITDDQVEG---FAKLIRLFIQLTLSSFHGFLVALQYGFANGEV

O95966/400-659......KHYLSLLSYVGCVVSALACLVTIAAYLCSRRK-----------------------------PRDYTIK-VHMNLLLAVFLLDTSFLLSEPVALTGSEAG------------------------------------------------------------------------------CR-ASAIFLHFSLLTCLSWMGLEGYNLYRLV-----VEVFGTYVPGYLLKLSAMGWGFPIFLVLVALVDVDNYGPIILAVHRTPEGVIYPSMC-WIRDS----LVSYITNLLFSLVFLFNMAMLATMVV-QILRLRP-H------TQKWS---------------------------------------------------------------------------------HVLTLLGLSLVLGLPWALIFFSFASG------TFQLVVLYLFSIITSFQGFLIFIWYWSMRLQA

O97807/782-1029.....ELLLTVITWVGIVISLVCLAICIFT-FCFFRG-----------------------------LQSDRNT-IHKNLCINLFIAEFIFLIGIDKTKYMIA--------------------------------------------------------------------------------CP-IFAGLLHFFFLAAFAWMCLEGVQLYLML------VEVFESEYSRKKYYYVAGYLFPATVVGVSAAID-------------YKSYGTEKAC-WLHVD---NYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSN--T-----LKPDSSRL-------------------ENIK-------------------------------------------------------SWVLGAFALLCLLGLTWSFGLLFINE--------ETIVMAYLFTIFNAFQGVFIFIFHCALQKKV

O97818/874-1121.....DLLLDVITWVGILLSLVCLLICIFT-FCFFRG-----------------------------LQSDRNT-IHKNLCISLFVAELLFLIGINRTDQPIA--------------------------------------------------------------------------------CA-VFAALLHFFFLAAFTWMFLEGVQLYIML------VEVFESEHSRRKYFYLVGYGMPALIVAVSAAVD-------------YRSYGTDKVC-WLRLD---TYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTA--I-----LKPESGCL-------------------DNIK-------------------------------------------------------SWVIGAIALLCLLGLTWAFGLMYINE--------STVIMAYLFTIFNSLQGMFIFIFHCVLQKKV

O97831/856-1103.....ELLLSVITWVGIVISLVCLAICIST-FCFLRG-----------------------------LQTDRNT-IHKNLCINLFLAELLFLVGIDKTQYEIA--------------------------------------------------------------------------------CP-IFAGLLHYFFLAAFSWLCLEGVHLYLLL------VEVFESEYSRTKYYYLGGYCFPALVVGIAAAID-------------YRSYGTEKAC-WLRVD---NYFIWSFIGPVSFVIVVNLVFLMVTLHKMVRSSS--V-----LKPDSSRL-------------------DNIK-------------------------------------------------------SWALGAIALLFLLGLTWAFGLLFINK--------ESVVMAYLFTTFNAFQGVFIFVFHCALQKKV

PACR_BOVIN/167-452..YLSVKALYTVGYSTSLVTLTTAMVI-LCRFRK-----------------------------LHCTRNF-IHMNLFVSFMLRAISVFIKDWILYAEQ-DSNHCFVST---------------------------------------------------------------------VECK-AVMVFFHYCVVSNYFWLFIEGLYLFTLL------VETFFPERRYFYWYIIIGWGTPTVCVSVWAMLR---------------LYFDDTGC-WDMND--NTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQS-P---DMGGNESSI---------------------YFS----------------------------CVQKCYCKPQRAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPEN-------VSKRERLVFELGLGSFQGFVVAVLYCFLNGEV

PACR_HUMAN/150-407..YLSVKALYTVGYSTSLVTLTTAMVI-LCRFRK-----------------------------LHCTRNF-IHMNLFVSFMLRAISVFIKDWILYAEQ-DSNHCFIST---------------------------------------------------------------------VECK-AVMVFFHYCVVSNYFWLFIEGLYLFTLL------VETFFPERRYFYWYTIIGWGTPTVCVTVWATLR---------------LYFDDTGC-WDMND--STALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQS-P---DMGGNESSI---------------------YLR--------------------------------------------------------LARSTLLLIPLFGIHYTVFAFSPEN-------VSKRERLVFELGLGSFQGFVVAVLYCFLNGEV

PACR_MOUSE/150-435..YLSVKALYTVGYSTSLVTLTTAMVI-LCRFRK-----------------------------LHCTRNF-IHMNLFVSFMLRAISVFIKDWILYAEQ-DSSHCFVST---------------------------------------------------------------------VECK-AVMVFFHYCVVSNYFWLFIEGLYLFTLL------VETFFPERRYFYWYTIIGWGTPTVCVTVWAVLR---------------LYFDDAGC-WDMND--STALWWVIKGPVVGSIMVNFVLFIGIIIILVQKLQS-P---DMGGNESSI---------------------YFS----------------------------CVQKCYCKPQRAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPEN-------VSKRERLVFELGLGSFQGFVVAVLYCFLNGEV

PACR_RAT/149-462....YLSVKALYTVGYSTSLATLTTAMVI-LCRFRK-----------------------------LHCTRNF-IHMNLFVSFMLRAISVFIKDWILYAEQ-DSSHCFVST---------------------------------------------------------------------VECK-AVMVFFHYCVVSNYFWLFIEGLYLFTLL------VETFFPERRYFYWYTIIGWGTPTVCVTVWAVLR---------------LYFDDAGC-WDMND--STALWWVIKGPVVGSIMVNFVLFIGIIIILVQKLQS-P---DMGGNESSI---------------------YLTNLRLRVPKKTREDPLPVPSDQHSPPFLSCVQKCYCKPQRAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPEN-------VSKRERLVFELGLGSFQGFVVAVLYCFLNGEV

PTH2_RAT/139-417....FENLYILYTVGYSISFGSLAVAILI-IGYFRR-----------------------------LHCTRNY-IHLHLFVSFMLRAXSIFVKDRVAQAHLGVEALQSLVMQGDLQNFIGGPS---------------------------------------------------VDKSQYVGCK-IAVVMFIYFLATNYYWILVEGLYLHNLI------FVSFFSDTKYLWGFILIGWGFPAVFVVAWAVAR---------------ATLADTRC-WELS---AGD-RWIYXXPILAAIGLNFILFLNTVRVLATKIWE---T-NAVGHDMRKQ---------------------YR-------------------------------------------------------KLAKSTLVLVLVFGVHYIVFICQPHS-FSG---LWWEIRMHCELFFNSFQGFFVSIVYCYCNGEV

PTR2_HUMAN/141-420..FERLYVMYTVGYSISFGSLAVAILI-IGYFRR-----------------------------LHCTRNY-IHMHLFVSFMLRATSIFVKDRVVHAHIGVKELESLIMQDDPQNSIEATS---------------------------------------------------VDKSQYIGCK-IAVVMFIYFLATNYYWILVEGLYLHNLI------FVAFFSDTKYLWGFILIGWGFPAAFVAAWAVAR---------------ATLADARC-WELS---AGDIKWIYQAPILAAIGLNFILFLNTVRVLATKIWE---T-NAVGHDTRKQ---------------------YR-------------------------------------------------------KLAKSTLVLVLVFGVHYIVFVCLPHS-FTG---LGWEIRMHCELFFNSFQGFFVSIIYCYCNGEV

PTRR_DIDMA/181-460..FDRLGMIYTVGYSISLGSLTVAVLI-LGYFRR-----------------------------LHCTRNY-IHMHLFVSFMLRAVSIFIKDAVLYSGVSTDEIERITEEELRAF-TEPPP---------------------------------------------------ADKAGFVGCR-VAVTVFLYFLTTNYYWILVEGLYLHSLI------FMAFFSEKKYLWGFTLFGWGLPAVFVAVWVTVR---------------ATLANTEC-WDLS---SGNKKWIIQVPILAAIVVNFILFINIIRVLATKLRE---T-NAGRCDTRQQ---------------------YR-------------------------------------------------------KLLKSTLVLMPLFGVHYIVFMATPYTEVSG---ILWQVQMHYEMLFNSFQGFFVAIIYCFCNGEV

PTRR_HUMAN/184-466..FDRLGMIYTVGYSVSLASLTVAVLI-LAYFRR-----------------------------LHCTRNY-IHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPA-------------------------------------------------TAAAGYAGCR-VAVTFFLYFLATNYYWILVEGLYLHSLI------FMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVR---------------ATLANTGC-WDLS---SGNKKWIIQVPILASIVLNFILFINIVRVLATKLRE---T-NAGRCDTRQQ---------------------YR-------------------------------------------------------KLLKSTLVLMPLFGVHYIVFMATPYTEVSG---TLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEV

PTRR_MOUSE/184-466..FDRLGMIYTVGYSMSLASLTVAVLI-LAYFRR-----------------------------LHCTRNY-IHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPA-------------------------------------------------AAAVGYAGCR-VAVTFFLYFLATNYYWILVEGLYLHSLI------FMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVR---------------ATLANTGC-WDLS---SGHKKWIIQVPILASVVLNFILFINIIRVLATKLRE---T-NAGRCDTRQQ---------------------YR-------------------------------------------------------KLLRSTLVLVPLFGVHYTVFMALPYTEVSG---TLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEV

PTRR_PIG/180-461....FDRLGMIYTVGYSVSLASLTVAVLI-LAYFRR-----------------------------LHCTRNY-IHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPLPPV-------------------------------------------------AATS-YVGCR-VAVTFFLYFLATNYYWILVEGLYLHSLI------FMAFFSEKKYLWGFTVFGWGLPAIFVAVWVSVR---------------ATLANTGC-WDLS---SGNKKWIIQVPILASIVLNFILFINIVRVLATKLRE---T-NAGRCDTRQQ---------------------YR-------------------------------------------------------KLLKSTLVLMPLFGVHYIVFMATPYTEVSG---TLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEV

PTRR_RAT/184-466....FDRLGMIYTVGYSMSLASLTVAVLI-LAYFRR-----------------------------LHCTRNY-IHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPA-------------------------------------------------AAAVGYAGCR-VAVTFFLYFLATNYYWILVEGLYLHSLI------FMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVR---------------ATLANTGC-WDLS---SGHKKWIIQVPILASVVLNFILFINIIRVLATKLRE---T-NAGRCDTRQQ---------------------YR-------------------------------------------------------KLLRSTLVLVPLFGVHYTVFMALPYTEVSG---TLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEV

Q10922/904-1150.....ASALDVVSTIGCAISIVCLALSVCV-FTFFRN-----------------------------LQNVRNS-IHRNLCLCLLIAELVFVIGMDRTGNRTG--------------------------------------------------------------------------------CG-VVAILLHYFFLSSFCWMLLEGYQLYMML------IQVFEPNRTRIFLYYLFCYGTPAVVVAISAGIK-------------WEDYGTDSYC-WIDTS---TPTIWAFVAPIIVIIAANIIFLLIALKVVLSVQS--R-----DRTKWGR---------------------IIG--------------------------------------------------------WLKGSATLLCLLGITWIFGFLTAVKG------GTGTAFAWIFTILNCTQGIFIFVLHVVLNEKV

Q17505/548-799......QTLLTLLTYVGCIISIICLLLTFFA-YLIFSR-----------------------------NGGDRVF-IHENLCLSLAIAEITFLAGITRTEDSLQ--------------------------------------------------------------------------------CG-IIAVALMYMFLSALTWMLLEGYHIHRML------TEVFPSDP-RRFTYLLVGYIPPAIITLVAYLYN-------------SDGFGTPDHC-WLSTQ---NNFIWFFAGPACFIFCANSLVLVKTLCTVYQHTSGGY---LPCRHDVDSG-------------------RSIR-------------------------------------------------------NWVKGSLALASLLGVTWIFGLFWVED-------SRSIVMAYVFTISNSLQGLFIFLFHVVFAEKM

Q92566/1858-2101....ILPLKTLTYVALGVTLAALLLTFFF-LTLLRI-----------------------------LRSNQHG-IRRNLTAALGLAQLVFLLGINQADLPFA--------------------------------------------------------------------------------CT-VIAILLHFLYLCTFSWALLEALHLYRAL------TEVRDVNTGPMRFYYMLGWGVPAFITGLAVGLD-------------PEGYGNPDFC-WLSIY---DTLIWSFAGPVAFAVSMSVFLYILAARA--------S-----CAAQRQGF-------------------EKK-----------------------------------------------------GPVSGLQPSFAVLLLLSATWLLALLSVNS--------DTLLFHYLFATCNCIQGPFIFLSYVVLSKEV

Q98955/1-202........-------------MSLLTLISALLV-LTIFRK-----------------------------LHCTRNY-IHANLFASFGLRATSVMVKDALLERRWGQRAAGGPIG------------------------------------------------------------RHWLSHEAALGCRAAQ-VLMQYCILANHYWFLVEAVYLYKLL------IGAVFSEKNYYRLYLYLGWGTPVVFVVPWMAAK---------------YLKENAEC-WALNE--NMAYWWIIRTPILLASMINLLIFICIIRILVQKLHS-P---DVGHNETS-----------------------LR--------------------------------------------------------LAGSTI----------------------------------------------------------

Q9YHC6/126-382......FGAIKTGYTIGHSLSLISLTAAMII-LCIFRK-----------------------------LHCTRNY-IHMHLFMSFIMRAIAVFIKDIVLFESG-ESDHCHVGS---------------------------------------------------------------------VGCK-AAMVFFQYCIMANFFWLLVEGLYLHNLL------VISFFSEKKYFWWYILIGWGAPSVFITAWSLAR---------------VYFEDTGC-WDTIE---SHLWWIIKTPILVSILVNFILFICIIRILVQKLHS-P---DVGRNENSQ---------------------YTR--------------------------------------------------------LAKSTLLLIPLFGVHYIMFAFFPDN-------FKVEVKLVFELILGSFQGFVVAVLYCFLNGEV

Q9YHC7/1-168........---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WLLVEGLYLHTLL------VVSFFSEWKYFCWYIALGWGSPLVFIIAWSVCR---------------HLYENTGC-WNINS--DASIWWIIRGPVILAIFINFILFINIIRVLATKLR--E-T-NAGRCDSRQ----------------------YK-------------------------------------------------------RLARSTLLLIPLFGVHYIIFAFFPEDVSS----GTVEIRLSFELALGSFQGFVVAILYCFFNGEV

Q9YHC8/1-167........---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WLLVEGLYLHNLL------VLVVFSERSYFMLYICIGWGAPVLFMAPWVAVK---------------YTYESDQC-WTINI--NMGYWWIIRSSVLLAITINFLIFMRIIQILLSKMRA-H---QMRYTDYRLLNIVRVLITKLKVTHQAESHLYLR--------------------------------------------------------LARSTLTLIPLLGIHEVVFALVTDETAMG---TLRLVKLFFDLFIGSFQGMLVAVLYCFLNGEV

Q9Z0M6/526-777......DPRLELITKVGLLLSLICLLLCILT-FLLVKP-----------------------------IQSSRTM-VHLHLCICLFLGSIIFLVGVENEGGEVG------------------------------------------------------------------------------LRCR-LVAMMLHFCFLAAFCWMALEGVELYFLV------VRVFQGQGLSTWQRCLIGYGVPLLIVAISMAVVK------------MDGYGHATYC-WLDFR--KQGFLWSFSGPVAFIIFCNAAIFVITVWKLTKKFS--E-----INPNMKKL-------------------RKA-----------------------------------------------------RVL-TITA-IAQLLVLGCTWGFGLFLFNP--------HSTWLSYIFTLLNCLQGLFLYVMLCLLNKKV

Q9Z0W0/175-443......LYTLQLMYTVGYSVSLISLFLALTL-FLFLRK-----------------------------LHCTRNY-IHMNLFASFILKVLAVLVKDMVSHNSYSKRPDDESGWMSYL-------------------------------------------------------------SETSVSCR-SVQVLLHYFVGTNHLWLLVEGLYLHTLL------EPTVFPERRLWPKYLVVGWAFPMLFVIPWGFAR---------------AHLENTRC-WATNG--NLKIWWIIRGPMLLCVTVNFFIFLKILKLLISKLKA-H---QMCFRDYK-----------------------YR--------------------------------------------------------LAKSTLLLIPLLGVHEVLFTFFPDDQVQG---FSKRIRLFIQLTLSSVHGFLVALQYGFANGEV

Q9Z2R4/462-705......ILPLKTLTYVALGVTLAALMLTFLF-LTLLRA-----------------------------LRSNQHG-IRRNLTAALGLAQLVFLLGINQADLPFA--------------------------------------------------------------------------------CT-VIAILLHFLYLCTFSWALLEALHLYRAL------TEVRDVNASPMRFYYMLGWGVPAFITGLAVGLD-------------PEGYGNPDFC-WLSVY---DTLIWSFAGPVAFAVSMSVFLYILSARA--------S-----CAAQRQGF-------------------EKK-----------------------------------------------------GPVSGLRSSFTVLRLLSATWLLALLSVNS--------DTLLFHYLFAACNCVQGPXIFXSYVVXSKEV

SCRC_HUMAN/139-395..LLKLKVMYTVGYSSSLVMLLVALGI-LCAFRR-----------------------------LHCTRNY-IHMHLFVSFILRALSNFIKDAVLFSSD-DVTYCDAHR---------------------------------------------------------------------AGCK-LVMVLFQYCIMANYSWLLVEGLYLHTLL------AISFFSERKYLQGFVAFGWGSPAIFVALWAIAR---------------HFLEDVGC-WDINA--NASIWWIIRGPVILSILINFILFINILRILMRKLRT-Q---ETRGNEVSH---------------------YKR--------------------------------------------------------LARSTLLLIPLFGIHYIVFAFSPED--------AMEIQLFFELALGSFQGLVVAVLYCFLNGEV

SCRC_RABIT/135-391..LLKLKVMYTVGYSSSLVMLLVALGI-LCAFRR-----------------------------LHCTRNY-IHMHLFLSFILRALSNFIKDAVLFSSD-DAIHCDAHR---------------------------------------------------------------------VGCK-LVMVFFQYCIMANYAWLLVEGLYLHSLL------VVSFFSERKCLQGFVVLGWGSPAMFVTSWAVTR---------------HFLEDSGC-WDINA--NAAIWWVIRGPVILSILINFILFINILRILTRKLRT-Q---ETRGQDMNH---------------------YKR--------------------------------------------------------LARSTLLLIPLFGVHYIVFVFSPEG--------AMEIQLFFELALGSFQGLVVAVLYCFLNGEV

SCRC_RAT/139-395....LLKLKVMYTVGYSSSLAMLLVALSI-LCSFRR-----------------------------LHCTRNY-IHMHLFVSFILRALSNFIKDAVLFSSD-DVTYCDAHK---------------------------------------------------------------------VGCK-LVMIFFQYCIMANYAWLLVEGLYLHTLL------AISFFSERKYLQAFVLLGWGSPAIFVALWAITR---------------HFLENTGC-WDINA--NASVWWVIRGPVILSILINFIFFINILRILMRKLRT-Q---ETRGSETNH---------------------YKR--------------------------------------------------------LAKSTLLLIPLFGIHYIVFAFSPED--------AMEVQLFFELALGSFQGLVVAVLYCFLNGEV

VIPR_CARAU/100-359..FRSVKIGYTIGHSVSLISLTTAIVI-LCMSRK-----------------------------LHCTRNY-IHMHLFVSFILKAIAVFVKDAVLYDVIQESDNCSTAS---------------------------------------------------------------------VGCK-AVIVFFQYCIMASFFWLLVEGLYLHALL------AVSFFSERKYFWWYILIGWGGPTIFIMAWSFAK---------------AYFNDVGC-WDIIE-NSDLFWWIIKTPILASILMNFILFICIIRILRQKINC-P---DIGRNESNQ---------------------YSR--------------------------------------------------------LAKSTLLLIPLFGINFIIFAFIPEN-------IKTELRLVFDLILGSFQGFVVAVLYCFLNGEV

VIPR_HUMAN/139-395..YGSVKTGYTIGYGLSLATLLVATAI-LSLFRK-----------------------------LHCTRNY-IHMHLFISFILRAAAVFIKDLALFDSG-ESDQCSEGS---------------------------------------------------------------------VGCK-AAMVFFQYCVMANFFWLLVEGLYLYTLL------AVSFFSERKYFWGYILIGWGVPSTFTMVWTIAR---------------IHFEDYGC-WDTI---NSSLWWIIKGPILTSILVNFILFICIIRILLQKLRP-P---DIRKSDSSP---------------------YSR--------------------------------------------------------LARSTLLLIPLFGVHYIMFAFFPDN-------FKPEVKMVFELVVGSFQGFVVAILYCFLNGEV

VIPR_MELGA/10-198...-----------------------------------------------------------------------------------------------------CFVSS---------------------------------------------------------------------VGCK-AMMVFFQYCVMANFFWLLVEGLYLHTLL------VISFFSERKYFWWYILIGWGAPSVFITAWTVVR---------------IYFFNVGC-WEEII--ESPIWWIIKTPILVSILVNFILFICIIRILVQKLR--P--PDIGKNDSSQ---------------------YSR--------------------------------------------------------LAKSTLLLIPLFGIHYIMFAFFPDN-------FKAQVKLVFELVVGSFQGFVVAVLYCFLNGEV

VIPR_MOUSE/1-149....-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FFSERKYFWGYILIGWGVPSVFIMIWTIVR---------------IHFEDFGC-WDTII--NSSLWWIIKGPILISILVNFILFVRIIRILMKKLR--T--SDVWGSDFNP---------------------YSR--------------------------------------------------------LAKSTLLLIPLFGVHYVMFAFFPDN-------FKAQVKMVFELVVGSFQGFVVAILYCFLNGEV

VIPR_PIG/140-396....YNSVKTGYTIGYSLSLAALLVATAI-LSLFRK-----------------------------LHCTRNY-IHMHLFISFILRATAVFIKDLALFDSE-ESDHCSKGS---------------------------------------------------------------------VGCK-AAVVLFQYCVMANFFWLLVEGLYLHTLL------AVSFFSERKYFWGYIFVGWGVPSTFIMVWTVVR---------------IHFEDYGC-WDTI---HSSLWWIIKAPILASILVNFILFIRIIGILVQKLRP-P---DVGKSDNSP---------------------YSR--------------------------------------------------------LAKSTLLLIPLFGVHYIMFAFFPDN-------FKAEVKMVFELIVGSFQGCVVAILYCFLNGEV

VIPR_RAT/140-397....YNTVKTGYTIGYSLSLASLLVAMAI-LSLFRK-----------------------------LHCTRNY-IHMHLFMSFILRATAVFIKDMALFNSG-EIDHCSEAS---------------------------------------------------------------------VGCK-AAVVFFQYCVMANFFWLLVEGLYLYTLL------AVSFFSERKYFWGYILIGWGVPSVFITIWTVVR---------------IYFEDFGC-WDTII--NSSLWWIIKAPILLSILVNFVLFICIIRILVQKLRP-P---DIGKNDSSP---------------------YSR--------------------------------------------------------LAKSTLLLIPLFGIHYVMFAFFPDN-------FKAQVKMVFELVVGSFQGFVVAILYCFLNGEV

VIPS_HUMAN/123-382..YILVKAIYTLGYSVSLMSLATGSII-LCLFRK-----------------------------LHCTRNY-IHLNLFLSFILRAISVLVKDDVLYSSS-GTLHCPDQPSSW------------------------------------------------------------------VGCK-LSLVFLQYCIMANFFWLLVEGLYLHTLL------VAMLPPRR-CFLAYLLIGWGLPTVCIGAWTAAR---------------LYLEDTGC-WDTND--HSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTS-P---DVGGNDQSQ---------------------YKR--------------------------------------------------------LAKSTLLLIPLFGVHYMVFAVFPIS-------ISSKYQILFELCLGSFQGLVVAVLYCFLNSEV

VIPS_MOUSE/122-381..YILVKAIYTLGYSVSLMSLTTGSII-ICLFRK-----------------------------LHCTRNY-IHLNLFLSFMLRAISVLVKDSVLYSSS-GLLRCHDQPASW------------------------------------------------------------------VGCK-LSLVFFQYCIMANFYWLLVEGLYLHTLL------VAILPPSR-CFLAYLLIGWGIPSVCIGAWTATR---------------LSLEDTGC-WDTND--HSIPWWVIRMPILISIVVNFALFISIVRILLQKLTS-P---DVGGNDQSQ---------------------YKR--------------------------------------------------------LAKSTLLLIPLFGVHYMVFAAFPIG-------ISSTYQILFELCVGSFQGLVVAVLYCFLNSEV

VIPS_RAT/122-381....YILVKAIYTLGYSVSLMSLTTGSII-ICLFRK-----------------------------LHCTRNY-IHLNLFLSFMLRAISVLVKDSVLYSSS-GTLRCHDQPGSW------------------------------------------------------------------VGCK-LSLVFFQYCIMANFYWLLVEGLYLHTLL------VAILPPSR-CFLAYLLIGWGIPSVCIGAWIATR---------------LSLEDTGC-WDTND--HSIPWWVIRMPILISIVVNFALFISIVRILLQKLTS-P---DVGGNDQSQ---------------------YKR--------------------------------------------------------LAKSTLLLIPLFGVHYMVFAAFPIG-------ISSTYQILFELCVGSFQGLVVAVLYCFLNSEV

YOW3_CAEEL/219-477..VEARILAGLLTYSASVIFLIPAVFL-LTLLRP-----------------------------IRCQPMFILHRHLLISCLLYGAFYLITVSLFVVNDAPLSSQ--------------------------------------------------------------------VFQNHLFCRLLFSIQLRYLRLTNFTWMLAEAVYLWRLL------HTAQHSEGETLRSYKVICWGVPGVITVVYIFVR--------------SLNDDVGMC-WIENS-TVAWIEWMIITPSLLAMGVNLLLK-----------------------------------------------------------------------------------------------------------AVRGALMLIPVFGVQQLLTIYRFSN--------TYYQVTDQSLNGLQGMFV--SFIVCYTNRSV

YQ44_CAEEL/267-539..ARNARKLEFVGLGLSLVSLILAISI-FSYFRR-----------------------------LRVFRNL-LHLHLMIAMLMVVILRLVLYIDLIFTG-ENGPHTNSAEGKTIP---------------------------------------------------------------IVCE-GMFFFLEYFKTVTFCWMFLEGIYLNNQI------VFGFFNSEPKLLPYFIAGYGIPLVHTMLWLLVV------------LIKKDFKVERCLGSYY---LEPEFWILDGPRMAELVINLFFICNVIRVLYSKVRE-S-----NNTSEA----------------------GLK-------------------------------------------------------KSVKAAMMLLPLLGVPNIMQTIPFAPTRDNI--MVFAVWTYTASFTYMYQGLMVASIYCFTNKEV